USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: O75832 USC-OGP 2-DE database:  O75832 O75832 General information about the entry View entry in simple text format Entry name PSD10_HUMAN Primary accession number O75832 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=26S proteasome non-ATPase regulatory subunit 10; AltName: Full=26S proteasome regulatory subunit p28; AltName: Full=Gankyrin; AltName: Full=p28(GANK);. Gene name Name=PSMD10 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0537: pI=5.54; Mw=24120 PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0809: pI=5.57; Mw=25339 Cross-references UniProtKB/Swiss-Prot O75832; PSD10_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PSD10_HUMAN Primary accession number O75832 Secondary accession number(s) Q5U0B2 Q8IZK9 Sequence was last modified on  November 1, 1998 (version 1) Annotations were last modified on  March 15, 2017 (version 172) Name and origin of the protein Description RecName: Full=26S proteasome non-ATPase regulatory subunit 10; AltName: Full=26S proteasome regulatory subunit p28; AltName: Full=Gankyrin; AltName: Full=p28(GANK); Gene name Name=PSMD10 Encoded on Name=PSMD10 Keywords 3D-structure; Alternative splicing; ANK repeat; Apoptosis; Chaperone; Complete proteome; Cytoplasm; Nucleus; Reference proteome; Repeat. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL AB009619; BAA33215.1; -; mRNA EMBL D83197; BAA34594.1; -; mRNA EMBL AY057056; AAL25260.1; -; mRNA EMBL AK295996; BAG58771.1; -; mRNA EMBL BT019689; AAV38495.1; -; mRNA EMBL AL031177; CAA20117.1; -; Genomic_DNA EMBL AL031177; CAI43131.1; -; Genomic_DNA EMBL BC011960; AAH11960.1; -; mRNA CCDS CCDS14536.1; -. [O75832-1]; . CCDS CCDS14537.1; -. [O75832-2]; . RefSeq NP_002805.1; NM_002814.3. [O75832-1]; . RefSeq NP_736606.1; NM_170750.2. [O75832-2]; . UniGene Hs.522752; -; . PDB 1QYM; X-ray; 2.80 A; A=2-226 PDB 1TR4; NMR; -; A=1-226 PDB 1UOH; X-ray; 2.00 A; A=1-226 PDB 4NIK; X-ray; 2.50 A; A=1-226 PDBsum 1QYM; -; . PDBsum 1TR4; -; . PDBsum 1UOH; -; . PDBsum 4NIK; -; . ProteinModelPortal O75832; -; . SMR O75832; -; . BioGrid 111688; 66; . DIP DIP-39026N; -; . IntAct O75832; 24; . MINT MINT-254757; -; . STRING 9606.ENSP00000217958; -; . ChEMBL CHEMBL2331054; -; . iPTMnet O75832; -; . PhosphoSitePlus O75832; -; . BioMuta PSMD10; -; . OGP O75832; -; . EPD O75832; -; . MaxQB O75832; -; . PaxDb O75832; -; . PeptideAtlas O75832; -; . PRIDE O75832; -; . TopDownProteomics O75832-1; -. [O75832-1]; . DNASU 5716; -; . Ensembl ENST00000217958; ENSP00000217958; ENSG00000101843. [O75832-1]; . Ensembl ENST00000361815; ENSP00000354906; ENSG00000101843. [O75832-2]; . GeneID 5716; -; . KEGG hsa:5716; -; . UCSC uc004enp.3; human. [O75832-1]; . CTD 5716; -; . DisGeNET 5716; -; . GeneCards PSMD10; -; . HGNC HGNC:9555; PSMD10; . HPA CAB010434; -; . HPA HPA002920; -; . MIM 300880; gene; . neXtProt NX_O75832; -; . OpenTargets ENSG00000101843; -; . PharmGKB PA33900; -; . eggNOG KOG4412; Eukaryota; . eggNOG COG0666; LUCA; . GeneTree ENSGT00870000136411; -; . HOGENOM HOG000158359; -; . HOVERGEN HBG053737; -; . InParanoid O75832; -; . KO K06694; -; . OMA CSAGHTN; -; . OrthoDB EOG091G0KEZ; -; . PhylomeDB O75832; -; . TreeFam TF106234; -; . Reactome R-HSA-1169091; Activation of NF-kappaB in B cells; . Reactome R-HSA-1234176; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; . Reactome R-HSA-1236974; ER-Phagosome pathway; . Reactome R-HSA-1236978; Cross-presentation of soluble exogenous antigens (endosomes); . Reactome R-HSA-174084; Autodegradation of Cdh1 by Cdh1:APC/C; . Reactome R-HSA-174113; SCF-beta-TrCP mediated degradation of Emi1; . Reactome R-HSA-174154; APC/C:Cdc20 mediated degradation of Securin; . Reactome R-HSA-174178; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; . Reactome R-HSA-174184; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; . Reactome R-HSA-180534; Vpu mediated degradation of CD4; . Reactome R-HSA-180585; Vif-mediated degradation of APOBEC3G; . Reactome R-HSA-187577; SCF(Skp2)-mediated degradation of p27/p21; . Reactome R-HSA-195253; Degradation of beta-catenin by the destruction complex; . Reactome R-HSA-202424; Downstream TCR signaling; . Reactome R-HSA-211733; Regulation of activated PAK-2p34 by proteasome mediated degradation; . Reactome R-HSA-2467813; Separation of Sister Chromatids; . Reactome R-HSA-2871837; FCERI mediated NF-kB activation; . Reactome R-HSA-349425; Autodegradation of the E3 ubiquitin ligase COP1; . Reactome R-HSA-350562; Regulation of ornithine decarboxylase (ODC); . Reactome R-HSA-382556; ABC-family proteins mediated transport; . Reactome R-HSA-450408; AUF1 (hnRNP D0) binds and destabilizes mRNA; . Reactome R-HSA-4608870; Asymmetric localization of PCP proteins; . Reactome R-HSA-4641257; Degradation of AXIN; . Reactome R-HSA-4641258; Degradation of DVL; . Reactome R-HSA-5358346; Hedgehog ligand biogenesis; . Reactome R-HSA-5362768; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; . Reactome R-HSA-5607761; Dectin-1 mediated noncanonical NF-kB signaling; . Reactome R-HSA-5607764; CLEC7A (Dectin-1) signaling; . Reactome R-HSA-5610780; Degradation of GLI1 by the proteasome; . Reactome R-HSA-5610783; Degradation of GLI2 by the proteasome; . Reactome R-HSA-5610785; GLI3 is processed to GLI3R by the proteasome; . Reactome R-HSA-5632684; Hedgehog 'on' state; . Reactome R-HSA-5658442; Regulation of RAS by GAPs; . Reactome R-HSA-5668541; TNFR2 non-canonical NF-kB pathway; . Reactome R-HSA-5676590; NIK-->noncanonical NF-kB signaling; . Reactome R-HSA-5678895; Defective CFTR causes cystic fibrosis; . Reactome R-HSA-5687128; MAPK6/MAPK4 signaling; . Reactome R-HSA-5689603; UCH proteinases; . Reactome R-HSA-5689880; Ub-specific processing proteases; . Reactome R-HSA-68827; CDT1 association with the CDC6:ORC:origin complex; . Reactome R-HSA-68949; Orc1 removal from chromatin; . Reactome R-HSA-69017; CDK-mediated phosphorylation and removal of Cdc6; . Reactome R-HSA-69229; Ubiquitin-dependent degradation of Cyclin D1; . Reactome R-HSA-69481; G2/M Checkpoints; . Reactome R-HSA-69601; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; . Reactome R-HSA-8852276; The role of GTSE1 in G2/M progression after G2 checkpoint; . Reactome R-HSA-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; . Reactome R-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation; . ChiTaRS PSMD10; human; . EvolutionaryTrace O75832; -; . GeneWiki PSMD10; -; . GenomeRNAi 5716; -; . PRO PR:O75832; -; . Proteomes UP000005640; Chromosome X; . Bgee ENSG00000101843; -; . CleanEx HS_PSMD10; -; . ExpressionAtlas O75832; baseline and differential; . Genevisible O75832; HS; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0005829; C:cytosol; IDA:HPA; . GO GO:0045111; C:intermediate filament cytoskeleton; IDA:HPA; . GO GO:0005654; C:nucleoplasm; TAS:Reactome; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0000502; C:proteasome complex; IDA:UniProtKB; . GO GO:0005838; C:proteasome regulatory particle; TAS:ProtInc; . GO GO:0008134; F:transcription factor binding; IPI:UniProtKB; . GO GO:0031145; P:anaphase-promoting complex-dependent catabolic process; TAS:Reactome; . GO GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I; TAP-dependent; TAS:Reactome GO GO:0006915; P:apoptotic process; IEA:UniProtKB-KW; . GO GO:0007253; P:cytoplasmic sequestering of NF-kappaB; IDA:UniProtKB; . GO GO:0038095; P:Fc-epsilon receptor signaling pathway; TAS:Reactome; . GO GO:0000165; P:MAPK cascade; TAS:Reactome; . GO GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB; . GO GO:0090090; P:negative regulation of canonical Wnt signaling pathway; TAS:Reactome; . GO GO:0043518; P:negative regulation of DNA damage response; signal transduction by p53 class mediator; IDA:UniProtKB GO GO:0010972; P:negative regulation of G2/M transition of mitotic cell cycle; TAS:Reactome; . GO GO:0043409; P:negative regulation of MAPK cascade; IMP:UniProtKB; . GO GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IDA:UniProtKB; . GO GO:0090201; P:negative regulation of release of cytochrome c from mitochondria; IMP:UniProtKB; . GO GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB; . GO GO:0051436; P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome; . GO GO:0038061; P:NIK/NF-kappaB signaling; TAS:Reactome; . GO GO:0090263; P:positive regulation of canonical Wnt signaling pathway; TAS:Reactome; . GO GO:0030307; P:positive regulation of cell growth; IDA:UniProtKB; . GO GO:0045737; P:positive regulation of cyclin-dependent protein serine/threonine kinase activity; IDA:UniProtKB; . GO GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IDA:UniProtKB; . GO GO:0031398; P:positive regulation of protein ubiquitination; IMP:UniProtKB; . GO GO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition; TAS:Reactome; . GO GO:0070682; P:proteasome regulatory particle assembly; IMP:UniProtKB; . GO GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; TAS:Reactome; . GO GO:0016579; P:protein deubiquitination; TAS:Reactome; . GO GO:0000209; P:protein polyubiquitination; TAS:Reactome; . GO GO:0006521; P:regulation of cellular amino acid metabolic process; TAS:Reactome; . GO GO:0043488; P:regulation of mRNA stability; TAS:Reactome; . GO GO:0061418; P:regulation of transcription from RNA polymerase II promoter in response to hypoxia; TAS:Reactome; . GO GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome; . GO GO:0002223; P:stimulatory C-type lectin receptor signaling pathway; TAS:Reactome; . GO GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome; . GO GO:0055085; P:transmembrane transport; TAS:Reactome; . GO GO:0033209; P:tumor necrosis factor-mediated signaling pathway; TAS:Reactome; . GO GO:0060071; P:Wnt signaling pathway; planar cell polarity pathway; TAS:Reactome Gene3D 1.25.40.20; -; 2; . InterPro IPR002110; Ankyrin_rpt; . InterPro IPR020683; Ankyrin_rpt-contain_dom; . Pfam PF00023; Ank; 1; . Pfam PF12796; Ank_2; 2; . PRINTS PR01415; ANKYRIN; . SMART SM00248; ANK; 5; . SUPFAM SSF48403; SSF48403; 1; . PROSITE PS50297; ANK_REP_REGION; 1; . PROSITE PS50088; ANK_REPEAT; 5; .

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